Drug interactions
Phenobarbital + Prochlorperazine
Severity: Moderate
Phenobarbital and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital and prochlorperazine both depress the CNS, so sedation, hypotension and impaired psychomotor function may be increased. Phenobarbital also induces hepatic enzymes and may lower phenothiazine levels. Phenothiazines can lower the seizure threshold, which may matter in epilepsy.
What this interaction means in plain words
Phenobarbital and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and enzyme induction by phenobarbital; phenothiazine lowering of seizure threshold.
What to do
Monitor sedation and seizure control and adjust anticonvulsant dosing if needed. Counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Phenobarbital with Prochlorperazine?
MediHelp rates the interaction as moderate. Phenobarbital and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital and prochlorperazine both depress the CNS, so sedation, hypotension and impaired psychomotor function may be increased. Phenobarbital also induces hepatic enzymes and may lower phenothiazine levels. Phenothiazines can lower the seizure threshold, which may matter in epilepsy.
How serious is the interaction between Phenobarbital and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and seizure control and adjust anticonvulsant dosing if needed. Counsel on avoiding driving and alcohol.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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