Drug interactions
Phenobarbital + Secukinumab
Severity: Minor
Phenobarbital and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab may normalize CYP enzyme expression suppressed by chronic inflammation, which could change phenobarbital clearance. Phenobarbital has a narrow therapeutic window. The effect is theoretical.
What this interaction means in plain words
Phenobarbital and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-17A blockade, potentially altering phenobarbital metabolism.
What to do
Monitor phenobarbital levels and seizure control when secukinumab is started or stopped. Adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Phenobarbital with Secukinumab?
MediHelp rates the interaction as minor. Phenobarbital and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab may normalize CYP enzyme expression suppressed by chronic inflammation, which could change phenobarbital clearance. Phenobarbital has a narrow therapeutic window. The effect is theoretical.
How serious is the interaction between Phenobarbital and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenobarbital levels and seizure control when secukinumab is started or stopped. Adjust the dose if needed.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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