Drug interactions
Phentolamine + Piroxicam
Severity: Minor
Phentolamine and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may blunt the blood pressure lowering effect of vasodilating antihypertensives through prostaglandin inhibition and sodium and fluid retention. The effect with phentolamine is theoretical and likely small.
What this interaction means in plain words
Phentolamine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phentolamine belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis by piroxicam may partly oppose alpha-blocker induced vasodilation.
What to do
Monitor blood pressure when piroxicam is started or stopped in a patient on phentolamine, and adjust the phentolamine dose if control is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Piroxicam?
MediHelp rates the interaction as minor. Phentolamine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may blunt the blood pressure lowering effect of vasodilating antihypertensives through prostaglandin inhibition and sodium and fluid retention. The effect with phentolamine is theoretical and likely small.
How serious is the interaction between Phentolamine and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when piroxicam is started or stopped in a patient on phentolamine, and adjust the phentolamine dose if control is reduced.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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