Drug interactions
Pilocarpine + Solifenacin
Severity: Moderate
Pilocarpine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and solifenacin is a muscarinic antagonist, so they oppose each other's effects. This may reduce the efficacy of either drug, for example less salivary stimulation or less bladder relaxation.
What this interaction means in plain words
Pilocarpine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced efficacy of pilocarpine (dry mouth relief) and of solifenacin (urgency symptoms). Adjust doses or choose an alternative if either therapeutic effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Solifenacin?
MediHelp rates the interaction as moderate. Pilocarpine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist and solifenacin is a muscarinic antagonist, so they oppose each other's effects. This may reduce the efficacy of either drug, for example less salivary stimulation or less bladder relaxation.
How serious is the interaction between Pilocarpine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of pilocarpine (dry mouth relief) and of solifenacin (urgency symptoms). Adjust doses or choose an alternative if either therapeutic effect is lost.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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