Drug interactions
Pimavanserin + Triclabendazole
Severity: Moderate
Pimavanserin and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so using them together may raise the risk of torsades de pointes. Triclabendazole is also metabolized via CYP enzymes, but the main concern is QT effects.
What this interaction means in plain words
Pimavanserin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and electrolytes and correct any abnormalities. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Pimavanserin with Triclabendazole?
MediHelp rates the interaction as moderate. Pimavanserin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so using them together may raise the risk of torsades de pointes. Triclabendazole is also metabolized via CYP enzymes, but the main concern is QT effects.
How serious is the interaction between Pimavanserin and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and correct any abnormalities. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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