Drug interactions
Pimozide + Propofol
Severity: Moderate
Pimozide and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide prolongs the QT interval and propofol can cause hypotension, bradycardia and additive sedation. Perioperative use may increase the risk of arrhythmia and deeper than expected sedation.
What this interaction means in plain words
Pimozide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular depression, with pimozide's QT prolongation adding arrhythmia risk.
What to do
Titrate propofol carefully with continuous ECG and blood pressure monitoring. Correct electrolytes before the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Pimozide with Propofol?
MediHelp rates the interaction as moderate. Pimozide and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide prolongs the QT interval and propofol can cause hypotension, bradycardia and additive sedation. Perioperative use may increase the risk of arrhythmia and deeper than expected sedation.
How serious is the interaction between Pimozide and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully with continuous ECG and blood pressure monitoring. Correct electrolytes before the procedure.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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