Drug interactions
Pimozide + Teriflunomide
Severity: Minor
Pimozide and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer, and CYP1A2 contributes to pimozide metabolism along with CYP3A4. Pimozide levels may fall slightly, though the clinical effect is probably small.
What this interaction means in plain words
Pimozide and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimozide belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak induction of CYP1A2 by teriflunomide, which increases pimozide clearance.
What to do
No routine adjustment is needed; monitor clinical response to pimozide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Pimozide with Teriflunomide?
MediHelp rates the interaction as minor. Pimozide and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer, and CYP1A2 contributes to pimozide metabolism along with CYP3A4. Pimozide levels may fall slightly, though the clinical effect is probably small.
How serious is the interaction between Pimozide and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response to pimozide.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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