Drug interactions
Pioglitazone + Risperidone
Severity: Moderate
Pioglitazone and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and hyperglycemia, which may counteract pioglitazone's glucose-lowering effect. Both drugs can also cause weight gain, which may compound metabolic risk.
What this interaction means in plain words
Pioglitazone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance opposes insulin sensitization.
What to do
Monitor glucose, HbA1c and weight, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Risperidone?
MediHelp rates the interaction as moderate. Pioglitazone and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and hyperglycemia, which may counteract pioglitazone's glucose-lowering effect. Both drugs can also cause weight gain, which may compound metabolic risk.
How serious is the interaction between Pioglitazone and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, HbA1c and weight, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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