Drug interactions
Pioglitazone + Stiripentol
Severity: Moderate
Pioglitazone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C8, the main pathway for pioglitazone metabolism. Pioglitazone exposure may rise, increasing fluid retention, edema, weight gain and hypoglycemia risk when used with other antidiabetics.
What this interaction means in plain words
Pioglitazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pioglitazone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C8, reducing pioglitazone clearance.
What to do
Monitor for edema, weight gain, heart failure signs and glucose changes after starting stiripentol. Reduce the pioglitazone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Stiripentol
Frequently asked questions
Can I take Pioglitazone with Stiripentol?
MediHelp rates the interaction as moderate. Pioglitazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP2C8, the main pathway for pioglitazone metabolism. Pioglitazone exposure may rise, increasing fluid retention, edema, weight gain and hypoglycemia risk when used with other antidiabetics.
How serious is the interaction between Pioglitazone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema, weight gain, heart failure signs and glucose changes after starting stiripentol. Reduce the pioglitazone dose if adverse effects occur.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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