Drug interactions
Pipemidic acid + Riluzole
Severity: Moderate
Pipemidic acid and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid is a quinolone that inhibits CYP1A2 and may raise riluzole concentrations. This could increase riluzole adverse effects such as liver enzyme elevation.
What this interaction means in plain words
Pipemidic acid and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP1A2 inhibition by pipemidic acid reduces riluzole clearance.
What to do
Prefer a non-CYP1A2-inhibiting antibiotic. If co-administered, monitor liver tests and riluzole tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pipemidic acid and Riluzole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Pipemidic acid with Riluzole?
MediHelp rates the interaction as moderate. Pipemidic acid and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pipemidic acid is a quinolone that inhibits CYP1A2 and may raise riluzole concentrations. This could increase riluzole adverse effects such as liver enzyme elevation.
How serious is the interaction between Pipemidic acid and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP1A2-inhibiting antibiotic. If co-administered, monitor liver tests and riluzole tolerability.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
