Drug interactions
Pirfenidone + Rucaparib
Severity: Moderate
Pirfenidone and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP1A2 inhibitor and can increase exposure to pirfenidone. This may worsen nausea, photosensitivity, and liver enzyme elevations.
What this interaction means in plain words
Pirfenidone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirfenidone belongs to Miscellaneous; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2, decreasing pirfenidone metabolism.
What to do
Monitor liver function and tolerability, and lower the pirfenidone dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Pirfenidone with Rucaparib?
MediHelp rates the interaction as moderate. Pirfenidone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP1A2 inhibitor and can increase exposure to pirfenidone. This may worsen nausea, photosensitivity, and liver enzyme elevations.
How serious is the interaction between Pirfenidone and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and tolerability, and lower the pirfenidone dose if adverse effects develop.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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