Drug interactions
Pirfenidone + Stiripentol
Severity: Moderate
Pirfenidone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce several CYP enzymes including CYP1A2, so pirfenidone exposure may rise or fall. This could cause increased adverse effects or reduced efficacy.
What this interaction means in plain words
Pirfenidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pirfenidone belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP1A2 inhibitory and inducing effects that alter pirfenidone clearance.
What to do
Monitor pirfenidone tolerability, liver tests and clinical response, and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Stiripentol
Frequently asked questions
Can I take Pirfenidone with Stiripentol?
MediHelp rates the interaction as moderate. Pirfenidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can inhibit and induce several CYP enzymes including CYP1A2, so pirfenidone exposure may rise or fall. This could cause increased adverse effects or reduced efficacy.
How serious is the interaction between Pirfenidone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pirfenidone tolerability, liver tests and clinical response, and adjust the dose as needed.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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