Drug interactions
Piroxicam + Pralatrexate
Severity: Moderate
Piroxicam and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal elimination of pralatrexate, which is cleared largely by the kidney. Higher exposure may increase mucositis, myelosuppression and other toxicities.
What this interaction means in plain words
Piroxicam and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal perfusion decrease pralatrexate clearance.
What to do
Monitor for mucositis, blood counts and renal function when piroxicam is given with pralatrexate, and reduce or hold pralatrexate per labeling if toxicity develops. Consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Piroxicam with Pralatrexate?
MediHelp rates the interaction as moderate. Piroxicam and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal elimination of pralatrexate, which is cleared largely by the kidney. Higher exposure may increase mucositis, myelosuppression and other toxicities.
How serious is the interaction between Piroxicam and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis, blood counts and renal function when piroxicam is given with pralatrexate, and reduce or hold pralatrexate per labeling if toxicity develops. Consider an alternative analgesic.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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