Drug interactions
Piroxicam + Prasugrel
Severity: Major
Piroxicam and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with prasugrel increases the risk of bleeding, notably gastrointestinal bleeding, because both impair platelet function and prasugrel is a potent antiplatelet drug.
What this interaction means in plain words
Piroxicam and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piroxicam belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Irreversible P2Y12 receptor blockade combined with cyclooxygenase inhibition and GI mucosal injury gives additive bleeding risk.
What to do
Avoid chronic NSAID use with prasugrel when possible and choose paracetamol for analgesia. If unavoidable, add gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Piroxicam with Prasugrel?
MediHelp rates the interaction as major. Piroxicam and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with prasugrel increases the risk of bleeding, notably gastrointestinal bleeding, because both impair platelet function and prasugrel is a potent antiplatelet drug.
How serious is the interaction between Piroxicam and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel when possible and choose paracetamol for analgesia. If unavoidable, add gastroprotection and monitor for bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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