Drug interactions
Piroxicam + Probenecid
Severity: Moderate
Piroxicam and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal tubular secretion of NSAIDs and can raise piroxicam concentrations, increasing the risk of gastrointestinal and renal adverse effects. Piroxicam may also work against the uricosuric purpose of probenecid to a minor extent.
What this interaction means in plain words
Piroxicam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters in the renal tubule, reducing piroxicam clearance.
What to do
Monitor for NSAID toxicity such as dyspepsia, GI bleeding and fluid retention, and use the lowest effective piroxicam dose. Consider a lower piroxicam dose or a different NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Piroxicam with Probenecid?
MediHelp rates the interaction as moderate. Piroxicam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal tubular secretion of NSAIDs and can raise piroxicam concentrations, increasing the risk of gastrointestinal and renal adverse effects. Piroxicam may also work against the uricosuric purpose of probenecid to a minor extent.
How serious is the interaction between Piroxicam and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID toxicity such as dyspepsia, GI bleeding and fluid retention, and use the lowest effective piroxicam dose. Consider a lower piroxicam dose or a different NSAID.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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