Drug interactions
Piroxicam + Rifapentine
Severity: Minor
Piroxicam and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces drug-metabolizing enzymes and may reduce piroxicam exposure, possibly weakening its therapeutic effect. The induction is somewhat less than rifampin but still relevant.
What this interaction means in plain words
Piroxicam and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Piroxicam belongs to Musculoskeletal; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induction of CYP2C9 increases piroxicam metabolism.
What to do
Monitor clinical response to piroxicam and adjust therapy if effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Piroxicam with Rifapentine?
MediHelp rates the interaction as minor. Piroxicam and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces drug-metabolizing enzymes and may reduce piroxicam exposure, possibly weakening its therapeutic effect. The induction is somewhat less than rifampin but still relevant.
How serious is the interaction between Piroxicam and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to piroxicam and adjust therapy if effect is lost.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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