Drug interactions
Piroxicam + Secobarbital
Severity: Minor
Piroxicam and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower piroxicam concentrations and reduce its analgesic or anti-inflammatory effect. The effect is likely modest.
What this interaction means in plain words
Piroxicam and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Piroxicam belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic enzymes including CYP2C9, increasing piroxicam metabolism.
What to do
No empiric dose change is needed. Reassess pain control and adjust the NSAID dose if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Piroxicam with Secobarbital?
MediHelp rates the interaction as minor. Piroxicam and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital may lower piroxicam concentrations and reduce its analgesic or anti-inflammatory effect. The effect is likely modest.
How serious is the interaction between Piroxicam and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Reassess pain control and adjust the NSAID dose if efficacy falls.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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