Drug interactions
Piroxicam + Sertraline
Severity: Moderate
Piroxicam and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding beyond that of either drug alone. Piroxicam carries a relatively high GI risk among NSAIDs.
What this interaction means in plain words
Piroxicam and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation, while NSAIDs inhibit platelets and damage gastric mucosa.
What to do
Avoid combining where possible, or add a proton pump inhibitor and use the lowest NSAID dose for the shortest time. Monitor for GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Piroxicam with Sertraline?
MediHelp rates the interaction as moderate. Piroxicam and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs increase the risk of upper gastrointestinal bleeding beyond that of either drug alone. Piroxicam carries a relatively high GI risk among NSAIDs.
How serious is the interaction between Piroxicam and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or add a proton pump inhibitor and use the lowest NSAID dose for the shortest time. Monitor for GI bleeding signs.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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