Drug interactions
Piroxicam + Sparsentan
Severity: Major
Piroxicam and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan blocks endothelin and angiotensin II receptors and lowers glomerular pressure, while NSAIDs constrict afferent arterioles. Together they can worsen kidney function and lessen blood pressure control.
What this interaction means in plain words
Piroxicam and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piroxicam belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
Combined renal hemodynamic effects: NSAID inhibition of vasodilatory prostaglandins with angiotensin receptor blockade lowers glomerular filtration.
What to do
Avoid regular NSAID use with sparsentan; if needed, use the shortest course and monitor serum creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Piroxicam with Sparsentan?
MediHelp rates the interaction as major. Piroxicam and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan blocks endothelin and angiotensin II receptors and lowers glomerular pressure, while NSAIDs constrict afferent arterioles. Together they can worsen kidney function and lessen blood pressure control.
How serious is the interaction between Piroxicam and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with sparsentan; if needed, use the shortest course and monitor serum creatinine, potassium and blood pressure.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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