Drug interactions
Piroxicam + Zafirlukast
Severity: Minor
Piroxicam and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam is cleared mainly by CYP2C9, which zafirlukast inhibits in vitro. Piroxicam has a long half-life, so even modest inhibition could raise exposure slightly, but clinical significance is uncertain.
What this interaction means in plain words
Piroxicam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Piroxicam belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast may inhibit CYP2C9-mediated metabolism of piroxicam.
What to do
No routine adjustment is needed. Monitor for GI discomfort or bleeding and use the lowest effective piroxicam dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Zafirlukast?
MediHelp rates the interaction as minor. Piroxicam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Piroxicam is cleared mainly by CYP2C9, which zafirlukast inhibits in vitro. Piroxicam has a long half-life, so even modest inhibition could raise exposure slightly, but clinical significance is uncertain.
How serious is the interaction between Piroxicam and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for GI discomfort or bleeding and use the lowest effective piroxicam dose.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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