Drug interactions
Pitavastatin + Teriflunomide
Severity: Minor
Pitavastatin and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8 and also affects BCRP. Pitavastatin is only minimally metabolized by CYP2C8, so a significant effect through that route is unlikely. Any increase in exposure is likely modest and would be mediated by transporters.
What this interaction means in plain words
Pitavastatin and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pitavastatin belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide inhibits CYP2C8 and BCRP, which may slightly raise pitavastatin exposure, although pitavastatin is cleared mainly by hepatic uptake and glucuronidation.
What to do
No routine dose adjustment is needed. Ask patients to report unexplained muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Pitavastatin with Teriflunomide?
MediHelp rates the interaction as minor. Pitavastatin and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8 and also affects BCRP. Pitavastatin is only minimally metabolized by CYP2C8, so a significant effect through that route is unlikely. Any increase in exposure is likely modest and would be mediated by transporters.
How serious is the interaction between Pitavastatin and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Ask patients to report unexplained muscle symptoms.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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