Drug interactions
Pitolisant + Trazodone
Severity: Moderate
Pitolisant and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval modestly and its labeling advises caution with other QT-prolonging drugs. Trazodone has QT-prolonging potential, so the combination raises arrhythmia risk, especially with other risk factors. Pitolisant exposure may also be raised by CYP2D6 inhibitors but trazodone is not a strong one.
What this interaction means in plain words
Pitolisant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitolisant belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Avoid in patients with congenital long QT syndrome or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Pitolisant with Trazodone?
MediHelp rates the interaction as moderate. Pitolisant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can prolong the QT interval modestly and its labeling advises caution with other QT-prolonging drugs. Trazodone has QT-prolonging potential, so the combination raises arrhythmia risk, especially with other risk factors. Pitolisant exposure may also be raised by CYP2D6 inhibitors but trazodone is not a strong one.
How serious is the interaction between Pitolisant and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Avoid in patients with congenital long QT syndrome or other QT-prolonging drugs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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