Drug interactions
Pneumococcal vaccine 13-valent + Rilonacept
Severity: Minor
Pneumococcal vaccine 13-valent and Rilonacept: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks IL-1 signalling and may have a small effect on vaccine responses, but this is not established. The pneumococcal conjugate vaccine is non-live, so it is not contraindicated and a clinically important interaction is unlikely.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Rilonacept have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Rilonacept belongs to Miscellaneous.
Why it happens
IL-1 blockade might theoretically reduce vaccine immunogenicity; this is not well established.
What to do
Give the vaccine on the usual schedule, ideally before starting rilonacept. Avoid live vaccines during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Rilonacept
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Rilonacept?
MediHelp rates the interaction as minor. Pneumococcal vaccine 13-valent and Rilonacept have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rilonacept blocks IL-1 signalling and may have a small effect on vaccine responses, but this is not established. The pneumococcal conjugate vaccine is non-live, so it is not contraindicated and a clinically important interaction is unlikely.
How serious is the interaction between Pneumococcal vaccine 13-valent and Rilonacept?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine on the usual schedule, ideally before starting rilonacept. Avoid live vaccines during treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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