Drug interactions
Pneumococcal vaccine 13-valent + Sirolimus
Severity: Minor
Pneumococcal vaccine 13-valent and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the immune response to the vaccine. As the vaccine is inactivated, it is safe and recommended in immunosuppressed patients.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR-mediated immunosuppression may blunt antibody production.
What to do
Vaccinate according to schedule, ideally before starting therapy; do not withhold.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Sirolimus?
MediHelp rates the interaction as minor. Pneumococcal vaccine 13-valent and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may reduce the immune response to the vaccine. As the vaccine is inactivated, it is safe and recommended in immunosuppressed patients.
How serious is the interaction between Pneumococcal vaccine 13-valent and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to schedule, ideally before starting therapy; do not withhold.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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