Drug interactions
Pneumococcal vaccine 13-valent + Tacrolimus
Severity: Minor
Pneumococcal vaccine 13-valent and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can reduce the antibody response to pneumococcal conjugate vaccine. The vaccine is inactivated and is recommended in immunosuppressed patients, so this is not a contraindication.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Calcineurin inhibition suppresses T-cell responses and may blunt vaccine immunogenicity.
What to do
Give the vaccine, preferably before transplantation or intensified immunosuppression. Do not withhold it.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pneumococcal vaccine 13-valent and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Tacrolimus?
MediHelp rates the interaction as minor. Pneumococcal vaccine 13-valent and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus can reduce the antibody response to pneumococcal conjugate vaccine. The vaccine is inactivated and is recommended in immunosuppressed patients, so this is not a contraindication.
How serious is the interaction between Pneumococcal vaccine 13-valent and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine, preferably before transplantation or intensified immunosuppression. Do not withhold it.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
