Drug interactions
Pomalidomide + Quinidine
Severity: Moderate
Pomalidomide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is metabolized partly by CYP3A4 and is a P-glycoprotein substrate. Quinidine inhibits P-glycoprotein and, more weakly, CYP3A4, so it may modestly raise pomalidomide exposure. The clinical effect is likely small.
What this interaction means in plain words
Pomalidomide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pomalidomide belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein and CYP3A4, which may reduce pomalidomide clearance.
What to do
Monitor for pomalidomide toxicity such as neutropenia and fatigue. Reduce the dose if adverse effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Quinidine?
MediHelp rates the interaction as moderate. Pomalidomide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is metabolized partly by CYP3A4 and is a P-glycoprotein substrate. Quinidine inhibits P-glycoprotein and, more weakly, CYP3A4, so it may modestly raise pomalidomide exposure. The clinical effect is likely small.
How serious is the interaction between Pomalidomide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pomalidomide toxicity such as neutropenia and fatigue. Reduce the dose if adverse effects increase.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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