Drug interactions
Pomalidomide + Secobarbital
Severity: Minor
Pomalidomide and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower pomalidomide exposure through enzyme induction. Pomalidomide is cleared mainly by CYP1A2 and to a lesser extent CYP3A4, so the effect is likely small.
What this interaction means in plain words
Pomalidomide and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by secobarbital may modestly increase pomalidomide clearance.
What to do
No dose change is required; monitor treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Secobarbital?
MediHelp rates the interaction as minor. Pomalidomide and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital may lower pomalidomide exposure through enzyme induction. Pomalidomide is cleared mainly by CYP1A2 and to a lesser extent CYP3A4, so the effect is likely small.
How serious is the interaction between Pomalidomide and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor treatment response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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