Drug interactions
Pomalidomide + Verapamil
Severity: Minor
Pomalidomide and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-glycoprotein substrate and is also metabolized partly by CYP3A4. Verapamil inhibits both pathways, but labeling reports no clinically important effect of P-gp inhibition on pomalidomide exposure, so a meaningful change is unlikely.
What this interaction means in plain words
Pomalidomide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-gp and CYP3A4, which could modestly raise pomalidomide levels.
What to do
No dose change is needed. Monitor for the usual pomalidomide adverse effects such as neutropenia and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Verapamil?
MediHelp rates the interaction as minor. Pomalidomide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-glycoprotein substrate and is also metabolized partly by CYP3A4. Verapamil inhibits both pathways, but labeling reports no clinically important effect of P-gp inhibition on pomalidomide exposure, so a meaningful change is unlikely.
How serious is the interaction between Pomalidomide and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for the usual pomalidomide adverse effects such as neutropenia and fatigue.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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