Drug interactions
Ponatinib + Posaconazole
Severity: Major
Ponatinib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib is a CYP3A4 substrate, so posaconazole may raise its exposure. This increases the risk of serious adverse effects such as arterial occlusion, hepatotoxicity, pancreatitis and heart failure.
What this interaction means in plain words
Ponatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ponatinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of ponatinib.
What to do
Avoid the combination if possible. If unavoidable, reduce the ponatinib dose per labeling and monitor for cardiovascular and hepatic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Posaconazole?
MediHelp rates the interaction as major. Ponatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponatinib is a CYP3A4 substrate, so posaconazole may raise its exposure. This increases the risk of serious adverse effects such as arterial occlusion, hepatotoxicity, pancreatitis and heart failure.
How serious is the interaction between Ponatinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, reduce the ponatinib dose per labeling and monitor for cardiovascular and hepatic toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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