Drug interactions
Ponesimod + Vedolizumab
Severity: Moderate
Ponesimod and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod reduces circulating lymphocytes and its effect persists after discontinuation. With vedolizumab, immunosuppression may be additive and raise the risk of infection.
What this interaction means in plain words
Ponesimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ponesimod belongs to Central Nervous System; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression via S1P receptor modulation and gut-selective integrin blockade.
What to do
Monitor for infection and check lymphocyte counts. When switching therapies, consider the prolonged pharmacodynamic effects of each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Ponesimod with Vedolizumab?
MediHelp rates the interaction as moderate. Ponesimod and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod reduces circulating lymphocytes and its effect persists after discontinuation. With vedolizumab, immunosuppression may be additive and raise the risk of infection.
How serious is the interaction between Ponesimod and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte counts. When switching therapies, consider the prolonged pharmacodynamic effects of each drug.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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