Drug interactions
Posaconazole + Pralsetinib
Severity: Major
Posaconazole and Pralsetinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pralsetinib is a substrate of CYP3A4 and P-glycoprotein, and posaconazole inhibits both. Exposure may rise, increasing the risk of hepatotoxicity, pneumonitis, hypertension and hemorrhage.
What this interaction means in plain words
Posaconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Pralsetinib belongs to Oncology.
Why it happens
Posaconazole inhibits CYP3A4 and P-glycoprotein, reducing pralsetinib clearance.
What to do
Avoid if an alternative exists. If coadministration is necessary, reduce the pralsetinib dose per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pralsetinib
Frequently asked questions
Can I take Posaconazole with Pralsetinib?
MediHelp rates the interaction as major. Posaconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pralsetinib is a substrate of CYP3A4 and P-glycoprotein, and posaconazole inhibits both. Exposure may rise, increasing the risk of hepatotoxicity, pneumonitis, hypertension and hemorrhage.
How serious is the interaction between Posaconazole and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If coadministration is necessary, reduce the pralsetinib dose per labeling and monitor for toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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