Drug interactions
Posaconazole + Progesterone intravaginal
Severity: Minor
Posaconazole and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole could slightly raise systemic progesterone concentrations, but vaginal administration limits first-pass metabolism and the clinical effect is expected to be small.
What this interaction means in plain words
Posaconazole and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4, which contributes to progesterone metabolism.
What to do
No dose change is usually needed; watch for progestogenic effects such as drowsiness or bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Progesterone intravaginal?
MediHelp rates the interaction as minor. Posaconazole and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole could slightly raise systemic progesterone concentrations, but vaginal administration limits first-pass metabolism and the clinical effect is expected to be small.
How serious is the interaction between Posaconazole and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for progestogenic effects such as drowsiness or bleeding changes.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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