Drug interactions
Posaconazole + Progesterone natural
Severity: Moderate
Posaconazole and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise exposure to natural progesterone given orally, producing more sedation, dizziness and progestogenic effects. The effect is lower with non-oral routes.
What this interaction means in plain words
Posaconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4, which metabolizes progesterone.
What to do
Monitor for sedation and other progestogenic effects and lower the progesterone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Progesterone natural?
MediHelp rates the interaction as moderate. Posaconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise exposure to natural progesterone given orally, producing more sedation, dizziness and progestogenic effects. The effect is lower with non-oral routes.
How serious is the interaction between Posaconazole and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other progestogenic effects and lower the progesterone dose if they occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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