Drug interactions
Posaconazole + Quazepam
Severity: Moderate
Posaconazole and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase quazepam and active metabolite concentrations, intensifying sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Posaconazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4, which is involved in quazepam metabolism.
What to do
Monitor for oversedation and consider lowering the quazepam dose, or choose a benzodiazepine cleared by glucuronidation such as lorazepam or temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Quazepam?
MediHelp rates the interaction as moderate. Posaconazole and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase quazepam and active metabolite concentrations, intensifying sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Posaconazole and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider lowering the quazepam dose, or choose a benzodiazepine cleared by glucuronidation such as lorazepam or temazepam.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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