Drug interactions
Posaconazole + Rabeprazole
Severity: Moderate
Posaconazole and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension and delayed-release tablets differ in acid dependence, but suspension absorption falls with raised gastric pH. Lower posaconazole levels may cause antifungal treatment failure or inadequate prophylaxis.
What this interaction means in plain words
Posaconazole and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dissolution and absorption of posaconazole, especially the oral suspension.
What to do
Prefer the delayed-release tablet or IV formulation with PPIs, or monitor posaconazole trough concentrations if suspension is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Rabeprazole?
MediHelp rates the interaction as moderate. Posaconazole and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole oral suspension and delayed-release tablets differ in acid dependence, but suspension absorption falls with raised gastric pH. Lower posaconazole levels may cause antifungal treatment failure or inadequate prophylaxis.
How serious is the interaction between Posaconazole and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the delayed-release tablet or IV formulation with PPIs, or monitor posaconazole trough concentrations if suspension is used.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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