Drug interactions
posaconazole + rifampin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ posaconazole exposure; avoid.
Mechanism of action
CYP3A4 induction/P-gp.
Clinical management
Avoid coadministration.
Drug reference
References
Frequently asked questions
Can I take posaconazole with rifampin?
The interaction is rated: Major. ↓ posaconazole exposure; avoid.
How serious is the interaction between posaconazole and rifampin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between posaconazole and rifampin managed?
Avoid coadministration.
Why do posaconazole and rifampin interact?
CYP3A4 induction/P-gp.
Full monographs, dosing and an interaction checker in the MediHelp app
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