Drug interactions
Posaconazole + Romidepsin
Severity: Major
Posaconazole and Romidepsin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase romidepsin exposure and both drugs are associated with QT prolongation. This raises the risk of toxicity including cardiac arrhythmia, myelosuppression and gastrointestinal effects.
What this interaction means in plain words
Posaconazole and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of romidepsin, with additive QT prolongation.
What to do
Obtain an ECG and check potassium and magnesium before and during treatment, and monitor for romidepsin toxicity; consider an alternative antifungal if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Romidepsin?
MediHelp rates the interaction as major. Posaconazole and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can increase romidepsin exposure and both drugs are associated with QT prolongation. This raises the risk of toxicity including cardiac arrhythmia, myelosuppression and gastrointestinal effects.
How serious is the interaction between Posaconazole and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium before and during treatment, and monitor for romidepsin toxicity; consider an alternative antifungal if feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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