Drug interactions
Posaconazole + Saccharomyces boulardii
Severity: Moderate
Posaconazole and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saccharomyces boulardii is a live yeast, and systemic or oral antifungals may reduce its viability and probiotic effect. Posaconazole's antifungal activity may therefore make the probiotic ineffective.
What this interaction means in plain words
Posaconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole has antifungal activity that may kill or inhibit the live yeast probiotic.
What to do
Avoid using the probiotic during posaconazole therapy and choose a non-yeast probiotic if one is needed. In immunocompromised patients, yeast probiotics are best avoided in any case.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Posaconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saccharomyces boulardii is a live yeast, and systemic or oral antifungals may reduce its viability and probiotic effect. Posaconazole's antifungal activity may therefore make the probiotic ineffective.
How serious is the interaction between Posaconazole and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the probiotic during posaconazole therapy and choose a non-yeast probiotic if one is needed. In immunocompromised patients, yeast probiotics are best avoided in any case.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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