Drug interactions
Posaconazole + Sodium bicarbonate
Severity: Minor
Posaconazole and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raising gastric pH can reduce dissolution and absorption of posaconazole oral suspension, though the effect is limited and mainly relevant to that formulation. Delayed-release tablets and intravenous posaconazole are largely unaffected.
What this interaction means in plain words
Posaconazole and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces dissolution of posaconazole oral suspension.
What to do
Prefer the delayed-release tablet or take the suspension with a full meal; check posaconazole levels if using suspension with frequent antacid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Posaconazole with Sodium bicarbonate?
MediHelp rates the interaction as minor. Posaconazole and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raising gastric pH can reduce dissolution and absorption of posaconazole oral suspension, though the effect is limited and mainly relevant to that formulation. Delayed-release tablets and intravenous posaconazole are largely unaffected.
How serious is the interaction between Posaconazole and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the delayed-release tablet or take the suspension with a full meal; check posaconazole levels if using suspension with frequent antacid use.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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