Drug interactions
Posaconazole + Sofosbuvir / velpatasvir
Severity: Minor
Posaconazole and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may modestly raise velpatasvir exposure because velpatasvir is partly metabolized by CYP3A4 and is a P-gp substrate. The increase is generally not considered clinically significant, but tolerability should be watched.
What this interaction means in plain words
Posaconazole and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by posaconazole may reduce velpatasvir clearance.
What to do
No dose adjustment is normally needed; monitor for adverse effects such as headache, fatigue and nausea during co-treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Posaconazole and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may modestly raise velpatasvir exposure because velpatasvir is partly metabolized by CYP3A4 and is a P-gp substrate. The increase is generally not considered clinically significant, but tolerability should be watched.
How serious is the interaction between Posaconazole and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; monitor for adverse effects such as headache, fatigue and nausea during co-treatment.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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