Drug interactions
Posaconazole + Tiagabine
Severity: Moderate
Posaconazole and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is metabolized mainly by CYP3A4, and posaconazole is a strong inhibitor of this enzyme. Tiagabine concentrations may increase, leading to dizziness, somnolence, tremor, confusion or seizures.
What this interaction means in plain words
Posaconazole and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of tiagabine, reducing its clearance.
What to do
Monitor for CNS adverse effects and seizure control, and reduce the tiagabine dose if toxicity appears. Reassess the dose when posaconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Tiagabine?
MediHelp rates the interaction as moderate. Posaconazole and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is metabolized mainly by CYP3A4, and posaconazole is a strong inhibitor of this enzyme. Tiagabine concentrations may increase, leading to dizziness, somnolence, tremor, confusion or seizures.
How serious is the interaction between Posaconazole and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and seizure control, and reduce the tiagabine dose if toxicity appears. Reassess the dose when posaconazole is stopped.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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