Drug interactions
Posaconazole + Triazolam
Severity: Major
Posaconazole and Triazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole markedly increases triazolam exposure, leading to prolonged sedation, confusion and respiratory depression. Azole antifungals that strongly inhibit CYP3A4 are generally advised against with oral triazolam.
What this interaction means in plain words
Posaconazole and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong inhibition of CYP3A4 reduces first-pass and systemic metabolism of triazolam.
What to do
Avoid the combination and use a benzodiazepine not dependent on CYP3A4, such as lorazepam or temazepam. If unavoidable, use a markedly reduced triazolam dose and monitor sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Triazolam?
MediHelp rates the interaction as major. Posaconazole and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole markedly increases triazolam exposure, leading to prolonged sedation, confusion and respiratory depression. Azole antifungals that strongly inhibit CYP3A4 are generally advised against with oral triazolam.
How serious is the interaction between Posaconazole and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a benzodiazepine not dependent on CYP3A4, such as lorazepam or temazepam. If unavoidable, use a markedly reduced triazolam dose and monitor sedation.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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