Drug interactions
Posaconazole + Ulipristal
Severity: Moderate
Posaconazole and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase ulipristal concentrations, which could enhance adverse effects. Ulipristal labeling advises against concomitant use with strong CYP3A4 inhibitors when used repeatedly, and exposure to a single emergency dose is less concerning.
What this interaction means in plain words
Posaconazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces ulipristal metabolism.
What to do
Avoid prolonged ulipristal regimens, such as for fibroids, with posaconazole. For single-dose emergency contraception, no adjustment is usually needed, but consider alternatives such as a copper IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Ulipristal?
MediHelp rates the interaction as moderate. Posaconazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase ulipristal concentrations, which could enhance adverse effects. Ulipristal labeling advises against concomitant use with strong CYP3A4 inhibitors when used repeatedly, and exposure to a single emergency dose is less concerning.
How serious is the interaction between Posaconazole and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged ulipristal regimens, such as for fibroids, with posaconazole. For single-dose emergency contraception, no adjustment is usually needed, but consider alternatives such as a copper IUD.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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