Drug interactions
Posaconazole + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Posaconazole and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can raise systemic vilanterol exposure, a beta-2 agonist. This may cause tachycardia, hypokalemia and QTc prolongation, and posaconazole itself prolongs QT.
What this interaction means in plain words
Posaconazole and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition increases systemic vilanterol exposure, with additive QT effects and adrenergic cardiovascular stimulation.
What to do
Monitor heart rate, potassium and ECG, especially in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative antifungal if cardiovascular adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Posaconazole and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and can raise systemic vilanterol exposure, a beta-2 agonist. This may cause tachycardia, hypokalemia and QTc prolongation, and posaconazole itself prolongs QT.
How serious is the interaction between Posaconazole and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and ECG, especially in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative antifungal if cardiovascular adverse effects occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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