Drug interactions
Posaconazole + Vilanterol / fluticasone furoate inhaled
Severity: Major
Posaconazole and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole strongly inhibits CYP3A4, which increases systemic exposure to both vilanterol and fluticasone furoate. This may cause beta-agonist cardiovascular effects, QTc prolongation, hypokalemia and corticosteroid systemic effects such as adrenal suppression.
What this interaction means in plain words
Posaconazole and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition raises systemic vilanterol and fluticasone furoate levels, with additive QT effects.
What to do
Avoid coadministration where possible, particularly for prolonged courses. If used, monitor ECG, potassium and signs of corticosteroid excess.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Posaconazole and Vilanterol / fluticasone furoate inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Posaconazole and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole strongly inhibits CYP3A4, which increases systemic exposure to both vilanterol and fluticasone furoate. This may cause beta-agonist cardiovascular effects, QTc prolongation, hypokalemia and corticosteroid systemic effects such as adrenal suppression.
How serious is the interaction between Posaconazole and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible, particularly for prolonged courses. If used, monitor ECG, potassium and signs of corticosteroid excess.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
