Drug interactions
Posaconazole + Vincristine liposomal
Severity: Contraindicated
Posaconazole and Vincristine liposomal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a CYP3A4 and P-gp substrate, and posaconazole inhibits both. Raised vincristine exposure has led to severe neurotoxicity, constipation or ileus and SIADH.
What this interaction means in plain words
Posaconazole and Vincristine liposomal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Posaconazole inhibits CYP3A4 and P-glycoprotein, reducing vincristine clearance.
What to do
Avoid the combination and use a non-azole antifungal such as an echinocandin during vincristine therapy. If exposure occurs, monitor closely for neuropathy and bowel dysfunction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Vincristine liposomal?
MediHelp rates the interaction as contraindicated. Posaconazole and Vincristine liposomal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vincristine is a CYP3A4 and P-gp substrate, and posaconazole inhibits both. Raised vincristine exposure has led to severe neurotoxicity, constipation or ileus and SIADH.
How serious is the interaction between Posaconazole and Vincristine liposomal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-azole antifungal such as an echinocandin during vincristine therapy. If exposure occurs, monitor closely for neuropathy and bowel dysfunction.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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