Drug interactions
Posaconazole + Zaleplon
Severity: Minor
Posaconazole and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is mainly metabolised by aldehyde oxidase with a smaller CYP3A4 contribution, so posaconazole may modestly increase its levels. Additional sedation and psychomotor impairment could result.
What this interaction means in plain words
Posaconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Zaleplon belongs to Central Nervous System.
Why it happens
Inhibition of the secondary CYP3A4 metabolic pathway of zaleplon.
What to do
No routine dose change; counsel about additive drowsiness and consider a lower zaleplon dose in elderly patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Posaconazole with Zaleplon?
MediHelp rates the interaction as minor. Posaconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zaleplon is mainly metabolised by aldehyde oxidase with a smaller CYP3A4 contribution, so posaconazole may modestly increase its levels. Additional sedation and psychomotor impairment could result.
How serious is the interaction between Posaconazole and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; counsel about additive drowsiness and consider a lower zaleplon dose in elderly patients.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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