Drug interactions
Posaconazole + Zanubrutinib
Severity: Moderate
Posaconazole and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases zanubrutinib exposure substantially. This raises the risk of toxicities such as bleeding, cytopenias and infection.
What this interaction means in plain words
Posaconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of zanubrutinib by posaconazole.
What to do
Reduce zanubrutinib to 80 mg once daily during strong CYP3A4 inhibitor use and monitor blood counts and for bleeding. Resume the usual dose after posaconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Posaconazole with Zanubrutinib?
MediHelp rates the interaction as moderate. Posaconazole and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole increases zanubrutinib exposure substantially. This raises the risk of toxicities such as bleeding, cytopenias and infection.
How serious is the interaction between Posaconazole and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg once daily during strong CYP3A4 inhibitor use and monitor blood counts and for bleeding. Resume the usual dose after posaconazole is stopped.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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