Drug interactions
Pralatrexate + Trastuzumab deruxtecan
Severity: Moderate
Pralatrexate and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the severity of neutropenia and infection.
What this interaction means in plain words
Pralatrexate and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pralatrexate belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression.
What to do
Monitor complete blood counts regularly and adjust or delay doses for significant neutropenia. Advise patients to report fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pralatrexate and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pralatrexate
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Pralatrexate with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Pralatrexate and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, and trastuzumab deruxtecan commonly causes neutropenia. Combined use may increase the severity of neutropenia and infection.
How serious is the interaction between Pralatrexate and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust or delay doses for significant neutropenia. Advise patients to report fever promptly.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
