Drug interactions
Pravastatin + Repaglinide
Severity: Minor
Pravastatin and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 substrate and may compete with pravastatin for hepatic uptake. Clinically meaningful changes are not well demonstrated.
What this interaction means in plain words
Pravastatin and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Possible competition at OATP1B1 hepatic uptake.
What to do
No routine adjustment is needed. Monitor for muscle symptoms and hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Pravastatin with Repaglinide?
MediHelp rates the interaction as minor. Pravastatin and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is an OATP1B1 substrate and may compete with pravastatin for hepatic uptake. Clinically meaningful changes are not well demonstrated.
How serious is the interaction between Pravastatin and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for muscle symptoms and hypoglycemia.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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